The number of confirmed cases of the coronavirus illness COVID-19 worldwide rose to 12.5 million on Saturday, with the U.S. accounting for about a quarter of that tally and the U.S. death toll rising again after a surge in infections in states in the South and West.

American states including Arizona are pleading for help with increasing testing, while other states say they are running short of personal protective equipment, or PPE, essential protection for health-care workers.

Public-health experts stepped up efforts to persuade Americans that the pandemic is far from over as some hospital systems are becoming overwhelmed.

“Somehow we thought that we could basically win an argument with this virus and now we know we can’t,” said Michael Osterholm, head of the Center for Infectious Disease Research and Policy at the University of Minnesota, in an interview with MSNBC.

Osterholm reiterated his argument that the only way to contain the spread, and to protect health and safety of people and the economy is to shut down “for once and for all, and then come back slowly and gradually like New York did and the rest of the world, and then live with it until we have a vaccine.”

Osterholm said one statistic that should be sobering is that 1,000 health-care workers have now died from COVID-19, most of whom contracted it through work. “And we’re running into a situation where we have even less protective equipment for these people and intensive-care units are running like M.A.S.H. units.

“We’ve got to lock this thing down and deal with the costs of it — but we gotta do it,” he said.

On Thursday, Dr. Anthony Fauci, head of the National Institute for Allergies and Infectious Diseases, who is considered to be the nation’s leading infectious-disease expert, urged states with rising infections to at least pause reopening efforts, giving them the chance to look “at what did not work well and try to mitigate that. … I don’t think we need to go back to an extreme of shutting down.”

See:CDC won’t revise guidelines for reopening schools, despite Trump claim

Fauci also lamented that partisanship has made the fight against coronavirus tougher. “When you don’t have unanimity in an approach to something, you’re not as effective in how you handle it,” he said in an interview Thursday with FiveThirtyEight’s PODCAST-19. “So I think you’d have to make the assumption that, if there wasn’t such divisiveness, that we would have a more coordinated approach.”

His comments came as President Donald Trump continued to point the finger at him for “mistakes,” including a mixed message on wearing face masks and for failing to support a ban on travelers from China early in the outbreak. “Dr. Fauci’s a nice man, but he’s made a lot of mistakes,” Trump said on Sean Hannity’s Fox News show.

Trump has rarely worn a mask in public and has not said Americans should wear masks.

There was grim news from Mississippi Health Officer Thomas Dobbs, who said Thursday that the state’s five biggest medical groups have run out of intensive-care-unit beds, the Washington Post reported. ‘Mississippi hospitals cannot take care of Mississippi patients,” Dobbs said.

Harvard Global Health Institute researchers have developed a national tracker to trace the severity of the outbreak on a state-by-state basis, and it’s flashing red for Arizona, Florida, Louisiana, South Carolina, Georgia and Alabama, with 25 cases per 100,000 people.

“Once a community reaches the red risk level, stay-at-home orders become necessary again,” the researchers wrote.

At least one of those states, Florida, is unlikely to consider shutting down again, after Gov. Ron DeSantis showed his determination to reopen schools in the Sunshine State in the fall, in line with Trump’s push this week, which has included threatening to withhold federal education funds. DeSantis drew criticism after saying that if retailers like Walmart and Home Depot are open, schools should be, too.

See: CDC won’t revise guidelines for reopening schools, despite Trump claim

The risk of children getting sick is “extremely, extremely low,” DeSantis said, according to a Tampa Bay Times report, and if stores are essential businesses during the pandemic, schools should reopen as well.

Sate education officials said they will stick with reopening plans that include online learning from home. Broward School Superintendent Robert Runcie told the South Florida Sun-Sentinel that “we do not see a realistic path” to schools opening five days a week.

While the virus initially proved fatal mostly for older people, young people and children have also seen horrifying side effects from the illness, including a rare but sometimes life-threatening condition that is being called multisystem inflammatory syndrome in children, or MIS-C. The condition presents with symptoms that often differ from kid to kid, and can include fever, stomach pain and rashes, as well as red eyes, loss of appetite and lethargy.

Earlier this week, U.K. neurologists published a report on how the virus can cause brain damage, including strokes, psychosis and paranoia in some patients.

From MarketWatch partner Financial News:Coronavirus R-rate rises in London as cases multiply

Latest tallies

There are now 12.5 million confirmed cases of COVID-19 worldwide, the Johns Hopkins data show. At least 560,921 people have died, while at least 6.9 million people have recovered.

Brazil is second to the U.S. with 1.80 million cases and 70,398 deaths.

India is third measured by cases that have climbed above 800,000 to 820,916, followed by Russia with 719,449 and Peru with 319,646.

The U.K. has 44,735 fatalities, the highest in Europe and third highest in the world.

China, where the illness was first reported late last year, has 84,992 cases and 4,641 fatalities.

What’s the latest medical news?

Gilead Sciences Inc.
GILD,
+2.15%

disclosed findings from a new internal analysis of previously disclosed clinical trial data that found the experimental therapy remdesivir can reduce the risk of mortality in COVID-19 patients by 62%, when compared with the standard of care, as MarketWatch’s Jaimy Lee reported.

Gilead said the mortality data point is “an important finding that requires confirmation in prospective clinical trials.”

The new analysis is not from a randomized, placebo-controlled clinical trial; it stems from a comparative, pre-planned analysis of 312 severely ill participants in a randomized, open-label Phase 3 trial and a real-world retrospective cohort of 818 patients with COVID-19 who had similar clinical attributes to those included in the trial and received remdesivir as part of their treatment.

The new analysis may also help reinforce previous conclusions from a randomized, placebo-controlled National Institutes of Health trial that found remdesivir can reduce recovery times, a finding that was published in April and contributed to the Food and Drug Administration’s decision in May to grant an emergency-use authorization to remdesivir.

What are companies saying?

United Airlines Holdings Inc.
UAL,
+8.28%

suffered another blow on Thursday, when S&P Global Ratings downgraded its debt by one notch to B+, pushing it further into junk-bond territory.

The ratings agency expects the airline to generate a “substantial cash-flow deficit,” thanks to a “steep decline” in bookings due to the pandemic. A return to positive cash flow is expected next year, S&P said. United is taking several steps to offset the reduced bookings, but these will not be enough, it said.

“As of now, we expect air traffic to begin to recover in the second half of 2020, but any delay will prolong weakness in credit metrics,” the ratings agency said.

There was better news from retailer Express Inc., which said sales and traffic are picking up now that about 95% of its stores have reopened after being closed during the pandemic. However, same-store sales and traffic declined in Arizona, California, Florida and Texas in late June, as COVID-19 cases began to spike.

Here’s the latest news about companies and COVID-19:

• Carrier is launching an air-filter machine to be used in institutional settings such as school classrooms, libraries and gyms, to help keep the air clear of contaminants and pathogens like the coronavirus. The heating, ventilating and air-conditioning company, part of Carrier Global Corp.
CARR,
+4.09%

after it was spun off the former United Technologies Corp. in May, said the new unit, called the OptiClean 1500-cfm Dual-Mode Air Scrubber & Negative Air Machine, joins an existing OptiClean 500-cfm unit, which was launched in April for use in hospitals. The machine can be plugged into a standard wall outlet and uses a long-life HEPA filter to improve indoor air quality. Chris Nelson, head of Carrier’s HVAC business, said the company is expecting the machine to help schools keep students and teachers safe as they prepare to reopen in the fall. The units are portable and take up just 3 square feet of floor space.

• Clothing retailer Express Inc.’s
EXPR,
+2.00%

same-store sales and traffic are improving as most of its stores have reopened after being closed for the coronavirus pandemic. The Columbus, Ohio–based company said about 95% of its stores are now open and the rest are expected to open in the coming weeks. Same-store sales have improved to negative 15% in the third week of June from negative 50% in early May. However, same-store sales and traffic declined in Arizona, California, Florida and Texas in late June, as COVID-19 cases began to spike. The company has buy-online-and-pickup-in-store capabilities at more than 275 locations and plans to have all stores enabled by the end of the third quarter. “Results in stores have been negatively impacted by multiple factors, including reduced mall traffic due to COVID-19 and the cancellation of June and July product, the latter causing the assortments to not yet be fully reflective of the Company’s new vision but deemed prudent in order to effectively manage liquidity,” said the company.

• Franklin Covey Co.
FC,
-3.02%
,
a maker of management and organization products and services, reported third-fiscal-quarter sales below expectations, and its quarterly loss was wider than expected as executives and educators switched to online learning amid closures to curb the spread of the coronavirus. All of the company’s business units “were adversely impacted by the closure of offices, schools, and other gathering places in the United States and in other countries” amid the pandemic, the company said. Training, coaching and consulting resulted in fewer sales for both its enterprise and education divisions; the education division also missed out on sales of materials and fewer coaching days as educators transitioned to online classes.

• Kroger Co.
KR,
+2.07%

rang up 75% higher sales for plant-based meat between the months of March and June 2020. Customer count for these items during the period rose by half. The data accompanied the results of a study conducted by the grocer and the Plant Based Foods Association that found plant-based-meat sales grew 23% when these items were placed in the meat department. Kroger sells plant-based-meat products under its Simple Truth private label, as well as plant-based brands like Beyond Meat Inc.
BYND,
-4.38%
.

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