AC Immune SA ACIU revealed knowledge from a Section 2 scientific trial of its wholly owned anti-alpha-synuclein (a-syn) lively immunotherapy candidate for early Parkinson’s illness.
Dr. Andrea Pfeifer, CEO of AC Immune, commented: “The extent of immunogenicity after solely 3 months of remedy in addition to the continued constructive security profile, reinforces the best-in-class traits of our clinically validated anti-a-syn lively immunotherapy for the remedy of Parkinson’s illness. We sit up for sharing additional updates in H1 2025 together with the choice to broaden into Half 2 of the VacSYn examine.”
VacSYn is an adaptive, placebo-controlled, and biomarker-based Section 2 examine in sufferers with early PD, consisting of two components.
Half 1 contains preliminary analyses from over 30 sufferers randomized to obtain ACI-7104.56 or placebo.
Up to now, no clinically related questions of safety have been reported apart from transient injection website reactions (49%) and complications (18%).
Interim outcomes present constructive antibody responses have been successfully induced in opposition to the goal antigen at week 6 after two immunizations and have been strongly boostable.
Remedy with the candidate, ACI-7104.056, induced a rise in anti-a-syn antibodies on common 16-fold greater than the placebo background stage after three immunizations.
Based mostly on additional interim outcomes, together with pharmacodynamic knowledge, to be reported in H1 2025, AC Immune might determine to provoke Half 2 of VacSYn with as much as 150 sufferers.
Sufferers from Half 2 will even be evaluated for the development of motor and non-motor signs of the illness, in addition to digital, imaging, and fluid biomarkers.
In Could, Takeda Pharmaceutical Firm Restricted TAK and AC Immune introduced an unique, worldwide possibility and license settlement for AC Immune’s lively immunotherapies concentrating on poisonous types of amyloid beta (Abeta), together with ACI-24.060 for Alzheimer’s illness.
Worth Motion: AC Immune inventory is up 6.71% at $3.34 throughout the premarket session finally test Thursday.
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