Corcept Therapeutics Included CORT introduced on Monday that the ROSELLA Section 3 trial of relacorilant plus nab-paclitaxel in sufferers with platinum-resistant ovarian most cancers met its main endpoint of improved progression-free survival, as assessed by blinded impartial central evaluate (PFS-BICR).
In ROSELLA, sufferers handled with relacorilant and nab-paclitaxel chemotherapy skilled a 30% discount within the threat of illness development in comparison with sufferers handled with nab-paclitaxel alone.
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The median PFS-BICR was 6.5 months, in comparison with 5.5 months in sufferers who obtained nab-paclitaxel alone.
At an interim analysis of general survival (OS), sufferers handled with relacorilant plus nab-paclitaxel had a big enchancment in OS, with a median OS of 16.0 months, in comparison with 11.5 months for sufferers receiving nab-paclitaxel alone.
Relacorilant was well-tolerated and no new security indicators have been noticed.
The entire outcomes of ROSELLA might be introduced at a medical convention this yr.
The ROSELLA trial enrolled 381 sufferers with platinum-resistant ovarian most cancers.
Analyst Response:
- HC Wainwright maintains Corcept Therapeutics with a Purchase, elevating the worth goal from $115 to $150.
- Truist Securities maintains Corcept Therapeutics with a Purchase, elevating the worth goal from $76 to $150.
Value Motion: CORT is up 85.6% at $101.80 on the final test on Monday.
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