Gene Remedy For Deadly Uncommon Illness-Related Coronary heart Situation – Lexeo Therapeutics Candidate Exhibits Enhancements In Trials – Lexeo Therapeutics (NASDAQ:LXEO)

Lexeo Therapeutics, Inc. LXEO on Monday launched interim knowledge throughout all dose cohorts of LX2006 for Friedreich ataxia (FA) cardiomyopathy, a critical coronary heart situation in FA sufferers with a uncommon, inherited neuromuscular dysfunction. 

In each the Lexeo-sponsored SUNRISE-FA Section 1/2 trial and the Weill Cornell Medication investigator-initiated Section 1A trial, therapy with LX2006 was related to clinically important enhancements in cardiac biomarkers and practical measures, and elevated frataxin protein expression was noticed in all individuals with cardiac biopsies.

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Left ventricular mass index (LVMI), a surrogate of left ventricular hypertrophy and a predictor of cardiac morbidity and mortality in adults with hypertension:

• 5 of 6 individuals achieved >10% enchancment by a 12-month go to or sooner
• As of the newest go to, 5 of 6 individuals achieved LVMI measurements inside the regular vary.
• 27% imply enchancment in LVMI as of the newest go to
• 25% imply enchancment in LVMI by a 12-month go to or sooner
• Individuals handled in Cohorts 2 and three (mid- and high-dose) show better, dose-dependent enchancment at earlier time factors relative to Cohort 1 (low-dose)

Secondary cardiac biomarkers, practical measures, and patient-reported outcomes:

• 10 of 12 individuals achieved a discount in lateral wall thickness (LWT) on the newest go to.
• 11 of 12 individuals achieved >25% discount in high-sensitivity troponin I on the newest go to.
• Nearly all of individuals confirmed enhancements throughout practical measures.

Cardiac frataxin expression (assessed in SUNRISE-FA trial solely; n=8):

• All individuals achieved will increase in frataxin protein expression at 3 months
• Dose-dependent will increase had been noticed throughout cohorts on common, with a 115% imply enhance in Cohort 3 (n=4)

In Q2 2025, Lexeo expects to start enrollment in a potential pure historical past research, serving as a concurrent exterior management arm for the registrational research.

The corporate expects to provoke a registrational research by early 2026, with a possible efficacy readout in 2027.

Worth Motion: LXEO inventory is up 7.40% at $2.51 in the course of the premarket session on the final test Monday.

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