Novo Nordisk A/S NVO announced heading arises from sanctuary 1 Stage 3a test in the international sanctuary program.
SANCTUARY 1 is a 68-week, effectiveness, and also security test contrasting once-daily dental semaglutide 50 mg for weight administration to a sugar pill in 667 grownups with excessive weight or obese with several comorbidities.
Semaglutide is a peptide marketed by Novo Nordisk under Ozempic, Rybelsus, and also Wegovy for the long-lasting therapy of kind 2 diabetic issues or excessive weight.
The test attained its main endpoint by showing a statistically considerable and also exceptional weight-loss at week 68 with dental semaglutide 50 mg versus sugar pill.
Connected: Mayo Center Research Emphasizes Possible of Novo Nordisk’s Wegovy for Heart Wellness and also Fat Burning
When examining therapy results, if all individuals complied with therapy from a mean standard body weight of 105.4 kg, individuals treated with dental semaglutide 50 mg attained a statistically considerable weight-loss of 17.4% after 68 weeks contrasted to a 1.8% decrease with sugar pill.
Furthermore, 89.2% of those that obtained dental semaglutide 50 mg got to a weight management of 5% or even more after 68 weeks, contrasted to 24.5% with sugar pill.
When using the therapy plan estimand, individuals treated with dental semaglutide 50 mg attained a weight management of 15.1% contrasted to a decrease of 2.4% with sugar pill, and also 84.9% attained a weight management of 5% or even more, contrasted to 25.8% with sugar pill.
In the test, dental semaglutide 50 mg showed up to have a secure and also well-tolerated account. One of the most typical unfavorable occasions were stomach; the large bulk were light to modest and also lessened with time.
Novo Nordisk anticipates to apply for governing authorization in the united state and also the EU in 2023. The international launch of dental semaglutide 50 mg is contingent on profile prioritisations and also producing ability.
Rate Activity: NVO shares are up 0.13% at $170.77 on the last check Monday.
