Silexion Therapeutics Highlights New Preclinical Knowledge From Its Pancreatic Most cancers Research – Silexion Therapeutics (NASDAQ:SLXN)

Silexion Therapeutics Corp. SLXN revealed new preclinical outcomes demonstrating the synergistic efficacy of its SIL-204, together with parts of first-line chemotherapy for pancreatic most cancers.

The extra preclinical information present that SIL-204 displays important synergistic exercise with 5-fluorouracil and irinotecan — two primary parts generally utilized in pancreatic most cancers remedies — when examined in human pancreatic tumor cell strains harboring KRAS G12D mutations, the commonest mutation in pancreatic most cancers.

Additionally Learn: Silexion Investigational Pancreatic Most cancers Therapy Exhibits Promise In Animal Research

Synergistic exercise was additionally noticed with the chemotherapeutic agent gemcitabine.

• Synergistic exercise was noticed after the confluence of those tumor cell strains, reflecting how SIL-204 might improve the consequences of 5-fluorouracil and irinotecan when used collectively, in addition to that of gemcitabine. 
• In preclinical fashions, combining 5-fluorouracil and irinotecan with SIL-204 led to a big discount in most cancers cell confluence after about three days in comparison with remedy with the chemotherapy brokers alone. 

Silexion is planning to provoke toxicology research with SIL-204 inside the upcoming months and to advance SIL-204 into Section 2/3 medical trials within the first half of 2026, focusing initially on domestically superior pancreatic most cancers (LAPC).

In parallel, the corporate plans to provoke preclinical research for SIL-204 in colorectal most cancers fashions.

Concurrently, Silexion Therapeutics priced a public providing of three.7 million shares and warrants to buy as much as 3.7 million shares at a mixed worth of $1.35 per share and accompanying warrant, with gross proceeds of $5 million.

SLXN Value Motion: SLXN inventory is down 42.96% at 89 cents at publication Thursday.

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