Thursday, Vor Biopharma Inc. VOR introduced new medical information from its ongoing Section 1/2 VBP101 examine of sufferers with relapsed/refractory acute myeloid leukemia (AML) receiving trem-cel adopted by Mylotarg.
Pfizer Inc’s PFE Mylotarg is indicated for newly recognized CD33-positive AML in adults and relapsed or refractory AML CD33-positive acute myeloid leukemia in adults and pediatric sufferers two years and older.
The information demonstrated dependable engraftment, shielding from Mylotarg on-target toxicity, a broadened Mylotarg therapeutic window, and early proof of affected person profit.
“We’re inspired by this information and the potential profit that trem-cel together with Mylotarg might provide to sufferers in a illness that has extraordinarily poor outcomes even after transplant,” mentioned Eyal Attar, Vor Bio’s Chief Medical Officer. “With this information, we plan to discover a registrational trial whereas we proceed to pursue different synergistic alternatives for Vor Bio’s platform corresponding to VCAR33ALLO and VADC45.”
The information launched included 18 sufferers handled with trem-cel of which ten had acquired Mylotarg as of the information deadline of July 19, 2024. The information demonstrated:
- Dependable engraftment, with 100% of sufferers attaining major neutrophil engraftment (median 9 days) and sturdy platelet restoration (median 16.5 days).
- Shielding of the blood system, with maintained neutrophil and platelet counts throughout a number of Mylotarg doses of 0.5, 1, and a pair of mg/m2.
- Early proof suggests affected person profit as measured by relapse-free survival in comparison with revealed high-risk AML comparators.
Vor Bio plans to method the FDA to debate a pivotal trial design for trem-cel + Mylotarg by across the finish of the yr.
Vor Bio introduced a brand new preclinical asset, VADC45, which has a number of potential alternatives in oncology, gene remedy, and autoimmune problems.
The corporate mentioned money, money equivalents, and marketable securities have been $85.9 million as of June 30, 2024, projected to fund operations into the second half of 2025.
Value Motion: VOR inventory is up 28.5percentat $1.06 eventually verify Friday.
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