Cognition Therapeutics, Inc. CGTX revealed optimistic outcomes from the exploratory Part 2 SHIMMER examine demonstrating that CT1812 produced sturdy therapeutic responses throughout behavioral, purposeful, cognitive and motion measures in sufferers with dementia with Lewy our bodies (DLB).
The SHIMMER Part 2 examine enrolled 130 sufferers with mild-to-moderate DLB who had been randomized to obtain considered one of two oral doses of CT1812 or placebo day by day for six months.
Outcomes indicated the examine met its major endpoint of security and tolerability. Information present that DLB sufferers handled with CT1812 for six months skilled enchancment in behavioral, purposeful, cognitive and motion measures in comparison with placebo.
There was an 82% slowing within the whole neuropsychiatric stock (NPI), with a very sturdy discount in anxiousness, hallucinations and delusions within the CT1812 handled arms.
As well as, there was a marked discount in caregiver misery, which suggests a optimistic influence on the day-to-day lives of these receiving the drug.
Contributors handled with CT1812 skilled a slowing decline throughout all three cognitive measures in comparison with placebo, together with fluctuations in consideration, which declined by 91%.
In July, Cognition Therapeutics reported that individuals within the proof-of-concept Part 2 ‘SHINE’ examine who had been handled with CT1812 for six months confirmed a constant pattern in cognitive enchancment in comparison with placebo throughout all cognitive measures.
As well as, there have been indicators of enchancment in purposeful measures.
As of September 30, 2024, money and money equivalents had been roughly $22.0 million. Complete grant funds remaining from the NIA had been $53.6 million. The Firm estimates it has ample money to fund operations and capital expenditures into the second quarter of 2025.
Worth Motion: CGTX inventory is up 93.45% at $0.88 finally examine on Wednesday mid-morning.
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Picture courtesy of Cognition Therapeutics
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